RESUMO
Background: HBe-antigen(Ag)-negative chronic hepatitis B virus (HBV) infection is characterized by little liver fibrosis progression and vigorous HBV-multispecific CD8+ T-cell response. Aims: To assess whether HBsAg level could discriminate different HBeAg-negative chronic HBV infection subtypes with dissimilar quality of HBV-specific CD8+ T-cell response. Methods: We recruited 63 HBeAg-negative chronic HBV infection patients in which indirect markers of liver inflammation/fibrosis, portal pressure, viral load (VL), and HBV-specific CD8+ cell effector function were correlated with HBsAg level. Results: A positive linear trend between HBsAg level and APRI, liver stiffness (LS), liver transaminases, and HBV VL, and a negative correlation with platelet count were observed. Frequency of cases with HBV-specific CD8+ T-cell proliferation against at least two HBV epitopes was higher in HBsAg < 1,000 IU/ml group. CD8+ T-cell expansion after HBVpolymerase456-63-specific stimulation was impaired in HBsAg > 1,000 IU/ml group, while the response against HBVcore18-27 was preserved and response against envelope183-91 was nearly abolished, regardless of HBsAg level. Cases with preserved HBVpolymerase456-63 CD8+ cell response had lower LS/duration of infection and APRI/duration of infection rates. HBV-polymerase456-63-specific CD8+ T-cell proliferation intensity was negatively correlated with LS/years of infection ratio. Conclusion: HBsAg > 1,000 IU/ml HBeAg-negative chronic HBV infection group shows indirect data of higher degree of inflammation, liver stiffness, and fibrosis progression speed, which are related to an impaired HBV-polymerase-specific CD8+ T-cell response.
Assuntos
Produtos do Gene pol , Hepatite B Crônica , Humanos , Vírus da Hepatite B/fisiologia , Antígenos de Superfície da Hepatite B/genética , Antígenos E da Hepatite B/genética , Inflamação , Cirrose Hepática , Linfócitos T CD8-Positivos , Alanina Transaminase , FenótipoRESUMO
No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Bacteriemia/complicações , Pancreatite Necrosante Aguda/complicações , Colangite/complicações , Colangite , Coledocolitíase/complicações , Piperacilina/uso terapêutico , Espectroscopia de Ressonância Magnética , Bacteriemia/tratamento farmacológico , ImunocompetênciaRESUMO
The bacterium Raoultella planticola (R planticola) is a rare pathogen in humans. We report a case of mild acute pancreatitis (MAP) of biliary origin with cholangitis and bacteremia with R planticola in association with pancreatic panniculitis (PP). We present the case report of a 55-year-old woman.
Assuntos
Bacteriemia/complicações , Bacteriemia/microbiologia , Colangite/complicações , Colangite/microbiologia , Pancreatite Necrosante Aguda/complicações , Pancreatite Necrosante Aguda/microbiologia , Doença Aguda , Antibacterianos/uso terapêutico , Bacteriemia/tratamento farmacológico , Colangite/diagnóstico por imagem , Enterobacteriaceae , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Pancreatite Necrosante Aguda/diagnóstico por imagem , Paniculite/complicações , Paniculite/microbiologia , Ácido Penicilânico/análogos & derivados , Ácido Penicilânico/uso terapêutico , Piperacilina/uso terapêutico , Combinação Piperacilina e TazobactamRESUMO
No disponible